Don't have any suggestions on wire routing but make sure it is heavy, 10ga would be ideal for those big 10s and lots of power. Prob do 12ga on the cans but unless you have multiple rolls of wire or are very space limited, bulk 10ga is prob the best option.
Personally, I have not had/seen good luck with isolators and high power stereos. You would be money ahead using a standard perko and put the rest into an additional battery and onboard charger.
System should rock the mids and highs! I bet this time next year you will be looking for subs to round out the system